Michael F Wempe Selected Research

procyanidin B2

1/2019	Differential effect of grape seed extract and its active constituent procyanidin B2 3,3″-di-O-gallate against prostate cancer stem cells.
1/2018	Procyanidin B2 3,3″-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK.
1/2014	Procyanidin B2 3,3(″)-di-O-gallate, a biologically active constituent of grape seed extract, induces apoptosis in human prostate cancer cells via targeting NF-κB, Stat3, and AP1 transcription factors.
3/2012	Glucuronidation and methylation of procyanidin dimers b2 and 3,3″-di-o-galloyl-b2 and corresponding monomers epicatechin and 3-o-galloyl-epicatechin in mouse liver.

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Michael F Wempe Research Topics

Disease

21	Neoplasms (Cancer) 10/2021 - 01/2010
5	Body Weight (Weight, Body) 01/2019 - 01/2010
4	Pancreatic Neoplasms (Pancreatic Cancer) 10/2020 - 07/2013
4	Prostatic Neoplasms (Prostate Cancer) 01/2019 - 01/2014
3	Medulloblastoma 01/2019 - 01/2016
3	Acute Kidney Injury (Acute Renal Failure) 01/2019 - 01/2017
3	Carcinogenesis 01/2016 - 10/2011
3	Hyperplasia 07/2014 - 01/2013
2	Chronic Renal Insufficiency 12/2022 - 01/2012
2	Low Cardiac Output 09/2021 - 01/2019
2	Hypertriglyceridemia 01/2021 - 01/2019
2	Ischemia 01/2020 - 01/2019
2	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 11/2015
2	Epilepsy (Aura) 01/2020 - 01/2020
2	Inflammation (Inflammations) 01/2019 - 01/2017
2	Brain Diseases (Brain Disorder) 01/2019 - 01/2019
2	Pyridoxine-dependent epilepsy 01/2019 - 01/2019
2	Hyperuricemia 01/2018 - 11/2010
2	Carcinoma (Carcinomatosis) 06/2017 - 03/2012
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2016 - 03/2015
2	Hypertension (High Blood Pressure) 01/2012 - 11/2010
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2012 - 11/2010
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2022
1	Lupus Nephritis 01/2022
1	Nephritis 01/2022
1	Melanoma (Melanoma, Malignant) 10/2021
1	Cognitive Dysfunction 01/2021
1	Amyloidosis 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Hypercholesterolemia 01/2021
1	Lung Diseases (Lung Disease) 01/2021
1	Cystic Fibrosis (Mucoviscidosis) 01/2021
1	Memory Disorders (Memory Loss) 01/2021
1	Thrombocytopenia (Thrombopenia) 02/2020
1	Glioma (Gliomas) 01/2020
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2020
1	Reperfusion Injury 01/2020
1	Diffuse Intrinsic Pontine Glioma 01/2020

Drug/Important Bio-Agent (IBA)

9	Amino Acid Transport Systems (Amino Acid Transporter)IBA 01/2019 - 01/2010
7	Pharmaceutical PreparationsIBA 01/2021 - 06/2007
6	2- amino- 3- (4- ((5- amino- 2- phenylbenzo(d)oxazol- 7- yl)methoxy)- 3,5- dichlorophenyl)propanoic acidIBA 11/2017 - 01/2010
5	Biomarkers (Surrogate Marker)IBA 01/2019 - 07/2013
5	Essential Amino AcidsIBA 01/2019 - 09/2013
4	Adenosine Triphosphate (ATP)IBA 01/2020 - 03/2015
4	Grape Seed ExtractIBA 01/2019 - 03/2012
4	procyanidin B2IBA 01/2019 - 03/2012
4	EnzymesIBA 01/2018 - 07/2013
4	Amino Acids FDA Link 01/2018 - 11/2014
4	Dibutyl Phthalate (Butyl Phthalate)IBA 07/2014 - 01/2013
3	Milrinone (Primacor)FDA LinkGeneric 09/2021 - 01/2018
3	Gemcitabine FDA Link 10/2020 - 01/2018
3	Pyridoxine (Pyridoxin)FDA LinkGeneric 01/2019 - 01/2019
3	Phosphotransferases (Kinase)IBA 01/2018 - 06/2013
3	Uric Acid (Urate)IBA 01/2017 - 11/2010
2	Adenosine Monophosphate (AMP)IBA 09/2021 - 09/2019
2	LipidsIBA 01/2021 - 04/2011
2	Phosphates (Orthophosphate)IBA 01/2020 - 01/2018
2	Dronabinol (THC)FDA LinkGeneric 01/2020 - 07/2016
2	CarnosineIBA 01/2020 - 01/2019
2	Large Neutral Amino Acid-Transporter 1IBA 01/2018 - 01/2016
2	FructoseIBA 01/2018 - 01/2017
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2018 - 06/2013
2	Neutral Amino AcidsIBA 11/2017 - 01/2014
2	Oxygen (Dioxygen)IBA 06/2017 - 10/2016
2	Testosterone (Sustanon)FDA Link 01/2017 - 01/2013
2	adavosertibIBA 04/2016 - 01/2016
2	Cisplatin (Platino)FDA LinkGeneric 04/2016 - 01/2016
2	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2016 - 10/2011
2	Transcription Factors (Transcription Factor)IBA 01/2016 - 01/2014
2	Oxidoreductases (Dehydrogenase)IBA 03/2015 - 02/2014
2	Pyruvic Acid (Pyruvate)IBA 03/2015 - 02/2014
2	Proteins (Proteins, Gene)FDA Link 02/2014 - 11/2010
1	Midazolam (Versed)FDA LinkGeneric 12/2022
1	Cholecalciferol (Vitamin D3)FDA Link 12/2022
1	25-hydroxyvitamin DIBA 12/2022
1	Imatinib Mesylate (Gleevec)FDA Link 01/2022
1	TeaIBA 10/2021
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 10/2021
1	Catechin (Z 7300)IBA 10/2021
1	Liver X ReceptorsIBA 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	PolymersIBA 01/2021
1	MicellesIBA 01/2021
1	Amyloid beta-PeptidesIBA 01/2021
1	Heparin (Liquaemin)FDA LinkGeneric 02/2020
1	bivalirudin (Angiomax)FDA Link 02/2020
1	AntithrombinsIBA 02/2020
1	AnticoagulantsIBA 02/2020
1	argatroban (MPQA)FDA Link 02/2020
1	CannabidiolIBA 01/2020
1	dipinacoline glutamateIBA 01/2020
1	DipeptidesIBA 01/2020
1	Histidine (L-Histidine)FDA Link 01/2020
1	Acrolein (Aqualin)IBA 01/2020
1	2-nonenalIBA 01/2020
1	Biological ProductsIBA 09/2019

Therapy/Procedure

6	Therapeutics 10/2021 - 11/2014
2	Drug Therapy (Chemotherapy) 01/2020 - 04/2016
2	Oral Administration 01/2016 - 07/2013
1	Immunotherapy 10/2021